SURGICAL GRINDING TOOL FOR MINIMALLY THERMAL INVASIVE SURGERY DURING BONE RESECTION (SALINE AS IRRIGATION)




The auto-inhibitory role of the EPAC hinge helix as mapped by NMR.

The cyclic-AMP binding domain (CBD) is the central regulatory unit of exchange proteins activated by cAMP (EPAC).The CBD maintains EPAC in a state of auto-inhibition in the absence of the allosteric effector, cAMP.When cAMP binds to the CBD such auto-inhibition is released, leading to EPAC activation.It has been shown that a key feature of such cAM

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